Abstract
The synthesis of a series of (3-phenylflavonoxy)propanolamines is described. These compounds were evaluated for potential antihypertensive activity in spontaneously hypertensive rats, as well as for in vivo and in vitro evidence of beta-adrenoceptor antagonism. Some of the compounds of this series exhibited effective antihypertensive properties but did not antagonize beta-adrenergic receptors. These active compounds represent a unique series of effective antihypertensive agents that, despite possessing structural characteristics typical of beta-blockers, does not have beta-adrenergic receptor blocking activity.
MeSH terms
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Adrenergic beta-Antagonists
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Animals
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Antihypertensive Agents / chemical synthesis
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Antihypertensive Agents / pharmacology
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Chemical Phenomena
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Chemistry
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Flavonoids / chemical synthesis
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Flavonoids / pharmacology
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Flavonoids / therapeutic use*
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Hypertension / drug therapy*
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Male
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Propanolamines / chemical synthesis
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Propanolamines / pharmacology
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Propanolamines / therapeutic use*
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Rats
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Rats, Inbred SHR
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Rats, Inbred WKY
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Receptors, Adrenergic, beta / drug effects*
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Structure-Activity Relationship
Substances
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Adrenergic beta-Antagonists
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Antihypertensive Agents
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Flavonoids
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Propanolamines
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Receptors, Adrenergic, beta